The DaVincibles

The DaVincibles is a Italian series about Zoe and Pablo going with their Uncle Leo to find, mostly art stuff, for Leo's antique shop named the Kurios Kat.

Plot
From qubo.com:

"From the pyramids of Egypt to the surface of the Moon, the DaVincibles are always looking for an adventure! The DaVincibles is a zany cartoon character comedy series packed with funny and absurd characters in search of wild, slapstick action. Pablo DaVinci and Zoe DaVinci have a serious sibling rivalry as they travel the world with their hilariously inept but loveable Uncle Leo to find artifacts to sell at his antique shop. The Society of Very Bad Villains (S.V.B.V.) and their leader Quba, the Picasso-faced worst artist in the world, must get the curious family of explorers out of their way in order for their evil plans to succeed. Even though the DaVincis frequently cross paths with them throughout their world travels, they stay invincible and keep the S.V.B.V. from obtaining world domination!"

Trivia

 * This is one of the few shows to start The Big Blowout!
 * The viral video "Charlie Bit My Finger" can be heard in "It's the Gargoyles"